Metabolic indicators hold key to preventing diabetes and heart disease
Insulin resistance and metabolic syndrome are at the heart of both type 2 diabetes and cardiovascular disease.
Dr. SM Grundy, MD, PhD, at the University of Texas Southwestern Medical Center, believes that, “approximately one-third of an apparently healthy population is sufficiently insulin-resistant to be at increased risk to develop type 2 diabetes, cardiovascular disease, high blood pressure, polycystic ovary disease, nonalcoholic liver disease and others.”
Focusing on metabolic syndrome, he states, will have the greatest impact on reducing the risk for cardiovascular disease.
Metabolic syndrome is usually defined as: waist circumference over 35 inches for women and 40 for men, fasting glucose over 100 mg/dL, blood pressure over 130/85, triglycerides over 150 mg/dL, HDL cholesterol less than 50 mg/dL for women and less than 40 mg/dL for men. Often, proinflammatory and prothrombotic factors are also considered, measured as elevated hs-CRP and fibrinogen, respectively.
To recognize the presence of metabolic syndrome and dysfunctional insulin signaling - before organs are damaged and a definitive disease takes place - Dr. Jeff Bland, PhD, FACN, FACB suggests that the best early-stage marker associated with insulin resistance is the shift of the apolipoprotein B and apoliprotein A-1 levels in the serum.
Apolipoprotein B is the primary apolipoprotein of low density lipoproteins (LDL or "lousy cholesterol"), which carries cholesterol to tissues. Apolipoprotein A-I is the major protein component of high density lipoprotein (HDL or “good cholesterol) in plasma that promotes cholesterol being excreted out of the body by the liver. These lipoproteins are affected by not only genes, but by diet, lifestyle, and environmental factors.
It has been well-documented that an elevated apolipoprotein B to apolipoprotein A-1 ratio is an important determinant of cardiovascular disease risk - independent of total serum cholesterol levels.
Dr Bland suggests that Apo B/apo A-1 ratio may be the most useful summary index of cardiovascular risk and that it is more helpful than the conventionally used LDL-cholesterol measurements and various other lipid ratios. The advantage also of the apo B/apo A-1 ratio is that it can be determined in non-fasting blood, unlike other cholesterol tests.
The lower the ratio, the lower the risk. A ratio of apo B/apo A-1 of 0.7 or lower would be considered a lower risk, whereas a ratio of 0.8 or higher would represent an increased risk.
More importantly, the apo B/apo A-1 is a very sensitive indicator of the change in insulin signaling and provides an early warning of the risk associated with metabolic syndrome, often leading to heart disease and type 2 diabetes.
Dr. Dennis Godby, Doctor of Naturopathy, Sutter Medical Foundation.
He may be reached online or at his Sacramento Office (916) 446-2591.
Placer County News HeadlinesHomeless Resource Helpline Launched in PlacerAUBURN, Calif. -- Placer County residents who are experiencing homelessness now have a new, centralized gateway to housing resources.
Kindergarten Registration in Eureka Union School DistrictRoseville, CA,- Registration for Transitional Kindergarten and Kindergarten will begin February 6th in the Eureka Union School District.
2018 William Jessup Baseball Season PreviewRocklin, Calif. - The Warriors are set to take the field for the first time in their 2018 stint ahead with great expectations under new head coach Jake McKinley and a solid recruiting class
SACOG New Board Leadership for 2018Sacramento - City of Sacramento Councilmember Jay Schenirer and City of Rancho Cordova Councilmember David Sander elected.
Donut Dash Benefit Registration Underway(Sacramento, Calif.) - The tenth annual Donut Dash will take place Saturday, March 3, at 8:30 a.m. at William Land Park in Sacramento. Proceeds will benefit the UC Davis Child Life and Creative Arts Therapy Department
BottleRock Napa Valley Lineup of Restaurants, Wineries, and Artisanal Craft Breweries & DistilleriesNAPA, CA, - Situated in the heart of America's wine and food playground, BottleRock Napa Valley, presented by JaM Cellars, has once again tapped into the region's renowned culinary talent
Thunder Valley Casino Hiring for Janitorial and HousekeepingLincoln, CA,- Thunder Valley Casino Resort is hiring for Janitorial and Housekeeping positions at a Job Fair on Wednesday,
School Strategies for Children with ADHD and ASD(Sacramento, Calif.) - On Wednesday, Jan. 24, the UC Davis MIND Institute and its Center for Excellence in Developmental Disabilities will host "School strategies for children with ADHD and ASD
916 Dialing Changes are Coming SoonOn February 09, 2017, the California Public Utilities Commission (CPUC) approved an overlay that will add the new area code 279 to the 916 area code region
Tree Harvest Festival billed as Northern California's first Cannabis Harvest FestivalWoodland, CA- We are proud to present Northern California's first Cannabis Harvest Festival. We will celebrate the 420 holiday with Music, Art, and Education
Mitsubishi Outlander remains affordable SUVRoseville, CA,- Cost-conscious car shoppers should give the 2018 Mitsubishi Outlander a look because it can be driven off the dealer lot for a very reasonable price.
Free Tax Assistance for Eligible ResidentsRocklin, CA- For the third year Placer County Health and Human Services will provide free tax assistance to low-income individuals and families, in cooperation with the IRS and United Way