Yellow Pages |   News Updates |   Events Calendar |   Movie Times | Recycling  |   Document Shredding
Rocklin & Roseville Today Events
Travel, Business and Entertainment Marketing
HOME

Metabolic indicators hold key to preventing diabetes and heart disease



Insulin resistance and metabolic syndrome are at the heart of both type 2 diabetes and cardiovascular disease.

Dr. SM Grundy, MD, PhD, at the University of Texas Southwestern Medical Center, believes that, “approximately one-third of an apparently healthy population is sufficiently insulin-resistant to be at increased risk to develop type 2 diabetes, cardiovascular disease, high blood pressure, polycystic ovary disease, nonalcoholic liver disease and others.” 

Focusing on metabolic syndrome, he states, will have the greatest impact on reducing the risk for cardiovascular disease.

Metabolic syndrome is usually defined as: waist circumference over 35 inches for women and 40 for men, fasting glucose over 100 mg/dL, blood pressure over 130/85, triglycerides over 150 mg/dL, HDL cholesterol less than 50 mg/dL for women and less than 40 mg/dL for men. Often, proinflammatory and prothrombotic factors are also considered, measured as elevated hs-CRP and fibrinogen, respectively.
To recognize the presence of metabolic syndrome and dysfunctional insulin signaling - before organs are damaged and a definitive disease takes place - Dr. Jeff Bland, PhD, FACN, FACB suggests that the best early-stage marker associated with insulin resistance is the shift of the apolipoprotein B and apoliprotein A-1 levels in the serum.

Apolipoprotein B is the primary apolipoprotein of low density lipoproteins (LDL or "lousy cholesterol"), which carries cholesterol to tissues.  Apolipoprotein A-I is the major protein component of high density lipoprotein (HDL or “good cholesterol) in plasma that promotes cholesterol being excreted out of the body by the liver.  These lipoproteins are affected by not only genes, but by diet, lifestyle, and environmental factors.
It has been well-documented that an elevated apolipoprotein B to apolipoprotein A-1 ratio is an important determinant of cardiovascular disease risk  - independent of total serum cholesterol levels.

Dr Bland suggests that Apo B/apo A-1 ratio may be the most useful summary index of cardiovascular risk and that it is more helpful than the conventionally used LDL-cholesterol measurements and various other lipid ratios. The advantage also of the apo B/apo A-1 ratio is that it can be determined in non-fasting blood, unlike other cholesterol tests.

The lower the ratio, the lower the risk.   A ratio of apo B/apo A-1 of 0.7 or lower would be considered a lower risk, whereas a ratio of 0.8 or higher would represent an increased risk.

More importantly, the apo B/apo A-1 is a very sensitive indicator of the change in insulin signaling and provides an early warning of the risk associated with metabolic syndrome, often leading to heart disease and type 2 diabetes.


Dr. Dennis Godby, Doctor of Naturopathy, Sutter Medical Foundation.

He may be reached online or at his Sacramento Office (916) 446-2591.



Placer County News Headlines

William Jessup University Announces Largest Graduating ClassROCKLIN, CA., - William Jessup University, the first WASC accredited private, four-year residential Christian university in the greater Sacramento region will celebrate its 77th annual

Sonoma County Outdoor Recreation Month in May SONOMA COUNTY, CALIFORNIA - Celebrate one of California's most diverse natural destinations as Sonoma County announces its inaugural Outdoor Recreation Month in May

Monophonics Sure is Funky at TerrapinSan Rafael,CA- As the mercury pushed into the 70's this past Friday, music fans began slowly dancing their way toward Terrapin Crossroads in San Rafael.

Storms Bring Good News for Water SupplyAUBURN, Calif. - Despite a dry start to 2018, storms in late March and early April have produced above-average precipitation in the watersheds that source Placer County Water Agency's

PCF Awards $18,000 in Grants to Promote Civil Discourse(Auburn, Calif.) - Open dialogue and communication are key elements in maintaining a healthy, connected community. To encourage debate, Placer Community Foundation

Dog Abandoned in Roseville under Inhumane CircumstancesRoseville, Calif. - A dog was found abandoned in a corner of the Atlantic Street Pet Emergency Center parking lot under terribly inhumane circumstances

Sun City Roseville Harmonicoots 2018 JamboreeRoseville, CA- This year, the Harmonicoots will honor all women harmonica players throughout the world at their Jamboree-scheduled for Thursday, May 8, 2018

Roseville Gas Prices Hold Steady Past Week Roseville, CA,- Roseville gas prices were relatively flat this past week, but remain at levels pushing near 2014 levels at some locations

Successful Transitions for Young Adults with Neurodevelopmental DisordersSacramento, CA- For many people with disabilities, the excitement of life after high school is accompanied by challenges with finding and receiving the services and supports

Passport Weekend Spectacular Fun in Fair PlayFair Play, CA- California is always full of surprise. This weekend marked our return to El Dorado Wines Passport Weekend.

Growing Weed in Placer County? Rules and ComplianceAuburn, CA - With Placer County's cannabis ordinance now in effect for over a year, county staff will host three drop-in meetings in May to answer questions about rules for cannabis cultivation

2018 Volkswagen SportWagen provides versatilityRoseville, CA,- Versatility is the 2018 Volkswagen SportWagen's main calling card, yet it has other enviable qualities that make it a good choice for car buyers.


more news